| 產(chǎn)品編號 |
V1704-HRP |
| 英文名稱 |
Prostate Specific Antigen
|
| 中文名稱 |
HRP標記的人前列腺特異性抗原單克隆抗體 |
| 克 隆 號 |
5F2 |
| 理論分子量 |
kDa |
| 檢測分子量 |
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| 緩 沖 液 |
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存條件 |
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事項 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
KLK3目前認為是前列腺癌很有意義的特異性標志物。激肽釋放酶KLK是激肽系統(tǒng)的主要限速酶，它是一組存在于多數(shù)組織和體液中的絲氨酸蛋白酶，是一種肽鏈內(nèi)切酶。KLK又稱血管舒緩素，包括15個家族成員。在不同的組織中廣泛表達,具有蛋白水解酶的活性。它特異性的在碳末端切割底物肽，可裂解激肽原釋放具有活性的激肽，由激肽發(fā)揮對心血管系統(tǒng)及腎臟功能的調(diào)節(jié)作用。
組織KLK是一個大的基因家族，主要分布在肺、腎、血管、腦、腎上腺組織，為一種中等大小的糖蛋白。
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